Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands. Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands; Dezima Pharma BV, Naarden, The Netherlands. Electronic address: j.s.jansen@amc.uva.nl. Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, Amsterdam, The Netherlands. Dezima Pharma BV, Naarden, The Netherlands; Department of Gastroenterology, Leiden University Medical Centre, Leiden, The Netherlands. Vascular Strategies, Horsham, PA, USA. Dezima Pharma BV, Naarden, The Netherlands; Xention Ltd, Cambridge, UK. Department of Genetics, Perelman School of Medicine, University of Pennsylvania, PA, USA.